Clinical trials have demonstrated that the timing of stem cells application substantially affect treatment success. It has been demonstrated in tendon injuries, that the later you apply the Stem Cell treatment, the less beneficial the effect is.
Likewise a direct correlation between the delay in the treatment application and increased risk of relapse has been shown.
This is because if the cells are applied too late, the organism has already begun its healing mechanisms, creating poor quality tissue which is not very elastic. If we apply the cells when this tissue has already been grown, the Stem Cells may not be as effective. On the other hand, local inflammation has to happen to activate the stem cells.
In summary it is concluded that the optimal time to treat an animal with Stem Cells is: ONE WEEK AFTER INJURY. That is, once the inflammatory phase is established, required for activation of cells, but before the proliferative phase.